Manuel Ugarte scored the winner as Uruguay advanced to the Copa America semi-finals with a 4-2 victory over Brazil on penalties.
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Ugarte settled the result after a 0-0 scrap featuring a tournament-high 41 fouls and just four shots on goal.
Uruguay advance to face Colombia in the semi-finals on Wednesday in Charlotte.
Colombia earlier Saturday routed Panama 5-0, extending its unbeaten streak to 27 matches.
Defending champion Argentina face Canada in the other semi-final on Tuesday in New Jersey.
Uruguay's triumph over Brazil came despite Nahitan Nandez being sent off after a red card in the 74th minute for a dangerous tackle on Rodrygo.
Uruguay led 3-1 after three rounds of the shootout when goalkeeper Sergio Rochet stopped Eder Militao and Douglas Luiz hit the post.
Alisson Becker saved Jose Maria Gimenez's shot in the fourth round to keep Brazil alive but Ugarte banged home the clincher.
Earlier, James Rodriguez scored one goal and set up two more as Colombia dismantled Panama 5-0.
Striker Jhon Cordoba outmuscled his marker to head in a corner and give Colombia the lead in the eighth minute, before captain Rodriguez smashed home a penalty after Panama goalkeeper Orlando Mosquera brought down Jhon Arias.
Colombia punished their opponents from another set piece in the 41st minute, as Rodriguez played in Luis Diaz with a quick free kick and the Liverpool winger lobbed his shot over Mosquera from the edge of the area.
Nestor Lorenzo's side eased off the throttle in the second half as they looked to control the game and see out the victory but were still able to muster another goal in the 70th minute when Richard Rios rifled in a low drive from range.
Panama's frustration appeared to show when defender Jose Cordoba clattered into Santiago Arias just inside the box to gift Colombia a clear penalty in stoppage time, which substitute Miguel Borja netted with the last kick of the match.
Australian Associated Press
