Understanding the long-term health impacts of bushfire smoke will be the focus of a new study.
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The study, funded by the Medical Research Future Fund's (MRFF) Bushfire Impact Research grants program, will seek to better understand the physiological impacts of prolonged bushfire smoke exposure.
The aim of the study is to improve health outcomes for Australians.
Centenary Institute deputy director and Centenary UTS Centre for Inflammation director Professor Phil Hansbro was the successful recipient of the grant.
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Professor Hansbro will lead a team of specialist respiratory disease researchers and clinicians on the project.
"The true extent of bushfire smoke on people is still largely unknown," said Professor Hansbro.
"We just don't know the full impact on people resulting from prolonged smoke inhalation or if short term effects resolve after the exposure ends.
"There is a real knowledge gap as to what level of smoke exposure is likely okay and what level may lead to adverse health effects, particularly for the more vulnerable in our society."
For this study, the research team will explore the short and prolonged physiological effects of bushfire smoke using mouse models and primary human cells and tissues.
Researchers will assess how bushfire smoke affects the airways, lungs and other organs and what the long-term consequences of this exposure could be.
They will also explore the potential impact on healthy individuals and those with common pre-existing respiratory disease such as asthma, emphysema and lung cancer.
"Ideally from our study, we'll be able to help define safe levels of bushfire smoke exposure across all of these population groups," Professor Hansbro said.
The researchers will then use their findings to evaluate new prevention strategies and treatment measures.
This will include the appraisal of anti-inflammatory drugs already in pre-clinical development that can be taken to help mitigate the effects of excessive bushfire smoke inhalation.
The aim is to implement the study findings into practice, as quickly as is practically possible.
Professor Hansbro is grateful for the opportunity provided by the federal government.
"Bushfires and smoke are a constant feature of the Australian environment and will continue to impact many of us, whether in the bush, towns or larger cities," he said.
"Our research will lead to improved knowledge in this critical area ultimately leading to improved health and wellbeing outcomes for many Australians."
